OT- Potential Game Changer another Covid thread
Well this is good news
https://finance.yahoo.com/news/roche-regeneron-collaborate-significantly-increase-050000652.html
REGN-COV2 was designed specifically by Regeneron scientists to block infectivity of SARS-CoV-2, the virus that causes COVID-19. They evaluated thousands of fully-human antibodies produced by the company's proprietary VelocImmune® mice, which have been genetically-modified to have a human immune system, as well as antibodies identified from humans who have recovered from COVID-19. The two potent, virus-neutralizing antibodies that form REGN-COV2 bind non-competitively to the critical receptor binding domain of the virus's spike protein, which diminishes the ability of mutant viruses to escape treatment and protects against spike variants that have arisen in the human population, as detailed in recent Science publications.
August 19th, 2020 at 2:01 AM ^
"We are excited about the potential for one medicine to serve both as a treatment for those infected as well as protection for people exposed to the virus. "
August 19th, 2020 at 9:27 AM ^
AWESOME! Also, thanks for dumbing down what the OP wrote. I feel like I'm a pretty smart guy, engineer, but wow, it was like talking to someone with a strong accent. I know it is english, and it sounded good, but there is no way I could have regurgitated what he(she?) said.
August 19th, 2020 at 9:40 AM ^
Upon closer inspection: the dumbed down content was written by the same person.
August 19th, 2020 at 9:55 AM ^
There's really no way to know.
August 19th, 2020 at 2:39 AM ^
This will be more of treatment and could be fast tracked in the next 30 days. Hopefully this will curve COVID and the B1G can start their season in October!
August 19th, 2020 at 6:38 AM ^
The B1G football season is done. Just forget about it.
August 19th, 2020 at 1:50 PM ^
At least Vader is practicing both social distancing and masking up....
August 19th, 2020 at 8:08 AM ^
Dude just let it go. The season is done and over, no matter how much we all think it sucks.
Can people stop thinking about football for two seconds? I’d say we all have far bigger concerns to address right now.
August 19th, 2020 at 10:03 AM ^
Not on MGoBlog dot com.
August 19th, 2020 at 6:07 PM ^
Why would you come to a Michigan sports blog site and expect to not talk about sports? There are plenty of places you can go to talk about the virus.
August 19th, 2020 at 2:52 AM ^
The last one of these was a stock pump and dump scheme. So I'm staying patient until their trials actually pan out.
August 19th, 2020 at 7:29 AM ^
Same here.
Time for the aluminum foil hat. I'm thinking of a particular industry here and how it demonstrates a general USA principle: Nothing gets done unless a well-connected person or group can make a shitload of money in the process.
August 19th, 2020 at 9:06 AM ^
So sad...so true.
OTOH, I would love to have something of this magnitude available to my wife to offer at the pediatric clinic. Hope springs eternal.
I hope they do not make college athletes into guinea pigs.
August 19th, 2020 at 9:50 AM ^
That princess never would have been saved by that guy and mog, if it weren't for making a shit load of money.
August 19th, 2020 at 10:33 AM ^
Great movie. My wife hates it when I have it on.
August 19th, 2020 at 9:09 AM ^
As a rule it is always a good idea to wait for pivotal human trial results. Animal data is largely meaningless to the average person and serves only to allow the company to move forward into human trials.
Announcing animal data is always to raise money, even at huge companies like Regeneron and Roche.
August 19th, 2020 at 10:38 AM ^
Yeah, but these aren’t any old mice we’re talking about. These are proprietary VelocImmune(r) mice!
August 19th, 2020 at 10:48 AM ^
Hello Moderna! Not sure if that's actually who you were talking about, but company leadership selling more than $226m of stock and giving up majority ownership in the process isn't something you do when you have a successful vaccine. Total pump and dump, they've got jack.
August 19th, 2020 at 3:05 AM ^
It's been expected for months that antibody therapies would be available in fall long before a vaccine. Problem is no one will be able to afford and unless they are on their death bed.
A true game changer would be something available and affordable as a prophylactic to front line and high risk people. Otherwise, not a game changer.
August 19th, 2020 at 7:56 AM ^
To go along with this, right now there's probably a very small window to make a boatload of money before mass vaccination becomes the standard and infections rate go down (hopefully). It's why there's not many companies investigating therapy for treatments once infected or exposed, and why the ones that are approved will cost half your retirement savings.
August 19th, 2020 at 11:45 AM ^
like Galidesivir?
Let's just say I am betting on BCRX to be the big game changer even if what I posted about affects me a lot more personally than what I can say on this board.
they are expensive to make, that's for sure
August 19th, 2020 at 3:06 AM ^
Well, if Yahoo! says it....
August 19th, 2020 at 6:34 AM ^
Binds non-competitively? Bro, we don’t have time for a scrimmage. Come back when it’s competitive.
{Shows self out}
August 19th, 2020 at 6:44 AM ^
Well, this is a relief. I read the title as "threat" instead of "thread". And I just got new glasses too.
August 19th, 2020 at 7:45 AM ^
Is anyone else less shocked about the potential COVID treatment than they are by the fact that this company MADE MICE WITH HUMAN IMMUNE SYSTEMS!?!?!?
August 19th, 2020 at 8:18 AM ^
...and here I was thinking we were already doing a stellar job of talking ourselves out of being the sapient species of record on Earth. We're even farther ahead than I believed apparently.
August 19th, 2020 at 8:34 AM ^
Our species is really working hard plotting its own extinction from this planet, isn't it? Buy hey, at least our scientists have provided access to male erections into our 90s, so we have that going for us...
August 19th, 2020 at 8:43 AM ^
That's just your FOMO kicking in!
August 19th, 2020 at 9:40 AM ^
That whole OP sounds like it's from some dystopian thriller. Even the name Regeneron is giving me the creeps.
August 19th, 2020 at 8:10 AM ^
That’s great. Even if it works, who’s going to be able to receive this in the short term aside from the stupid wealthy and the guy who is inches away from death?
Even if it works, it’s going to be a long time before it’s made readily available to the masses.
August 19th, 2020 at 8:43 AM ^
have those mice strap up so we can have a football season
and this is an interesting read:
https://www.nytimes.com/2020/08/19/opinion/coronavirus-risk-prevention.html
August 19th, 2020 at 8:52 AM ^
Well the good news is that Regeneron is definitely a company who has a track record that shows that they have the greater good in mind, and will do whatever it takes to make sure their pandemic related product is ethically and judiciously priced, after being 80% funded by the government, so that the maximum number of people can have access to it.
August 19th, 2020 at 9:18 AM ^
I sense sarcasm in this response, Captain.
August 19th, 2020 at 9:06 AM ^
I have no fucking idea what that means, but i think its probably good news.
August 19th, 2020 at 9:23 AM ^
Can we talk about the genetically altered mice with human immune systems?
August 19th, 2020 at 9:35 AM ^
Reaffirms my belief that some kind of mousepox will end up wiping out the human race because we got too big for our britches.
August 19th, 2020 at 10:34 AM ^
and now we WILL need a better mouse trap
August 19th, 2020 at 11:37 AM ^
Yep! All the benefits of being able to test a treatment in a human immune system at mass scale without all those pesky Josef Mengele comparisons and "crimes against humanity" when weird side effects show up.
August 19th, 2020 at 9:34 AM ^
Our daily COVID-19 game changer thread for August 19th.
August 19th, 2020 at 10:20 AM ^
Let's hope this remedy is effective. I'll look forward to positive media coverage.
August 19th, 2020 at 10:40 AM ^
If this is legitimate and it stops the binding process, then haven't they just found the cure for the common cold too? If I remember correctly, the common trait in coronavirus (COVID and the common cold among them) is the way they attach to the human cells. If they can stop the binding process for one, then shouldn't it work for the other as well?
August 19th, 2020 at 10:57 AM ^
A game-changer of a different sort:
"Our understanding of COVID-19 has accreted around the idea that it kills a few and is “mild” for the rest. That caricature was sketched before the new coronavirus even had a name; instead of shifting in the light of fresh data, it calcified. It affected the questions scientists sought to ask, the stories journalists sought to tell, and the patients doctors sought to treat. It excluded long-haulers from help and answers.
Nichols’s initial symptoms were so unlike the official description of COVID-19 that her first doctor told her she had acid reflux and refused to get her tested. “Even if you did have COVID-19, you’re 32, you’re healthy, and you’re not going to die,” she remembers him saying. (She has since tested positive.)"
August 19th, 2020 at 11:16 AM ^
You've brought to light here exactly the Covid-19 "conventional wisdom" that has driven me insane since the beginning of this pandemic; i.e., "mild" cases come and go unremarkably. While that can be true, it's also the case that so-called "asymptomatic" and "mild" cases can take many weeks to clear, and can ravage the body.
I have kept reminding friends and relatives who tell me about "asymptomatic" cases that cardiovascular disease is also frequently symptom-free ... Right up until the patient has a widow-maker heart attack and drops dead.
August 19th, 2020 at 1:25 PM ^
The vast majority of people don’t have any of the problems you mention.
Certain people WANT to fixate on the minority cases and present them as standard when in fact they are not
Fear distorts perception of reality.
August 19th, 2020 at 2:27 PM ^
Please provide your source. Thanks.
August 19th, 2020 at 12:50 PM ^
This is exciting obviously but I swear people don't understand just how many drugs look great (especially in press releases, which is what this link is) in initial trials but fail once they go into larger-scale testing. I worked at a major research university for a couple of years and saw numerous times where promising drugs failed when their scope expanded. Absolutely you hope one of these hits and becomes a viable treatment but it isn't going to necessarily happen in the next month or two, and there's a good chance that this treatment comes with unexpected side-effects that will show up during these trials.
August 19th, 2020 at 3:37 PM ^
I didn’t know they had mice engineered like that. Cool. I guess human plasma is the alternative source for IgX but carries the risk of being infectious so the mice thing is cool; as long as there’s no xenograft rejection issues.
August 19th, 2020 at 3:49 PM ^
That's a nice press release by Roche.
August 20th, 2020 at 6:35 PM ^
Inovio has the vaccine, INO4800. Unfortunately it will take a bit of time due to having to prove their new industry disrupting technology without help from lobbyists against big pharma's will. Fortunately their stock is cheap as hell for another couple weeks I would guess. Fauci, Moderna, etc such a crock of cronyism shit. Hope Regeneron has something here, we will need numerous solutions.